Biography roy suryo rote

  • This report also draws on
  • The chapters in the edited

    • Abstract

    Aims: Current treatment options for ovarian clear cell carcinoma (OCCC) are limited to combination of platinum-based and other cytotoxic agents to which patients respond poorly due to intrinsic chemoresistance. There is therefore an urgent need to develop alternative therapeutic strategies for OCCC.

    Results: Cysteine deprivation suppresses OCCC growth in vitro and in vivo with no apparent toxicity. Modes of cell death induced by cysteine deprivation in OCCC are determined by their innate metabolic profiles. Cysteine-deprived glycolytic OCCC is abolished primarily by oxidative stress-dependent necrosis and ferroptosis, which can otherwise be prevented by pretreatment with antioxidative agents. Meanwhile, OCCC that relies on mitochondria respiration for its bioenergetics is suppressed through apoptosis, which can otherwise be averted by pretreatment with cysteine precursor alone, but not with antioxidative agents. Cysteine deprivation induces apoptosis in respiring OCCC by limiting iron−sulfur (Fe−S) cluster synthesis in the mitochondria, without which electron transport chain may be disrupted. Respiring OCCC responds to Fe−S cluster deficit by increasing iron influx into the mitochondria, which leads to iron overload, mitochondria damage, and eventual cell death.

    Innovation: This study demonstrates the importance of cysteine availability in OCCC that is for its antioxidative property and its less appreciated role in mitochondria respiration. Regardless of OCCC metabolic profiles, cysteine deprivation abolishes both glycolytic and respiring OCCC growth in vitro and in vivo.

    Conclusion: This study highlights the therapeutic potential of cysteine deprivation for OCCC.

    Keywords: cysteine, cystathionase, system xc, oxidative stress, iron−sulfur cluster, mitochondria

    Introduction

    Epithelial ovarian cancer is classified into four major types based on histopathology: (i) serous, (ii) clear cell, (iii) endometrioid, and (iv) m

  • Students doing research on

    • Publications

    2025

    • Ehlers F., Slobbe C., Schlembach F., Kleinherenbrink M., Verlaan M.: Polygon-Informed Cross-Track Altimetry (PICTA): Estimating river water level profiles with the Sentinel-6 altimeter. Remote Sensing of Environment 316, 2025, 114479 more… Full text ( DOI )
    • Ehrhardt, Denise; Sommer, Felicitas; Ndim, Mouhamadou; Raimbault, Juste; Hartmann, Thomas; Jehling, Mathias: Who drives urban densification? Linking landownership and spatial dynamics. Raumforschung und Raumordnung \textbar Spatial Research and Planning, 2025 more… Full text ( DOI )
    • Fröch, Thomas; Kanna, Khaoula; Olbrich, Felix; Donaubauer, Andreas; Saad, Abdullah; Huang, Chenhao; Deng, Zihan; Sedlmaier, Marilena; Chen, Qiaoqiao; Thielen, Kai: Trendanalyse Intergeo 2024. zfv - Zeitschrift für Geodäsie, Geoinformation und Landmanagement (1/2025), 2025, 60-66 more…
    • Gruber T., Angermann D., Sánchez L.: Definition of Essential Geodetic Variables (EGV): Contribution of Geodesy to Earth Observation, White Paper. Global Geodetic Observing System (GGOS), 2025 more… Full text ( DOI ) Full text (mediaTUM)
    • Gruber, Thomas; Angermann, Detlef; Sánchez, Laura: Definition of Essential Geodetic Variables (EGV): Contribution of Geodesy to Earth Observation, White Paper. Global Geodetic Observing System (GGOS), 2025 more… Full text ( DOI )
    • Ikeya, Kosuke; Guerrero-Gonzalez, Francisco J.; Kiewiet, Luca; Cardin, Michel-Alexandre; Cilliers, Jan; Starr, Stanley; Hadler, Kathryn: Hybrid lunar ISRU plant: A comparative analysis with carbothermal reduction and water extraction. Acta Astronautica 230, 2025, 148-168 more… Full text ( DOI )
    • Luo, Hongyi; Luo, Peng; Meng, Liqiu: A Robust Geographically Optimal Zones-based heterogeneity model for analyzing the spatial determinants of national traffic accidents. GIScience & Remote Sensing 62

    Breaking boundaries: role of the brain barriers in metastatic process

    • Review
    • Open access
    • Published:
    • Nasim Izadi,
    • Peter Solár,
    • Klaudia Hašanová,
    • Alemeh Zamani,
    • Maryam Shahidian Akbar,
    • Klára Mrázová,
    • Martin Bartošík,
    • Tomáš Kazda,
    • Roman Hrstka &
    • …
    • Marek Joukal

    Fluids and Barriers of the CNSvolume 22, Article number: 3 (2025) Cite this article

    • 924 Accesses

    • 1 Altmetric

    • Metrics details

    Abstract

    Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3–10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. BMs predominantly originate from primary lung (20–56%), breast (5–20%), and melanoma (7–16%) tumors, although they can arise from other cancer types less frequently. The metastatic cascade is a multistep process involving local invasion, intravasation into the bloodstream or lymphatic system, extravasation into normal tissue, and colonization of the distal site. After reaching the brain, circulating tumor cells (CTCs) breach the blood–brain barrier (BBB).

    The selective permeability of the BBB poses a significant challenge for therapeutic compounds, limiting the treatment efficacy of BMs. Understanding the mechanisms of tumor cell interactions with the BBB is crucial for the development of effective treatments. This review provides an in-depth analysis of the brain barriers, including the BBB, blood-spinal cord barrier, blood-meningeal barrier, blood-arachnoid barrier, and blood-cerebrospinal fluid barrier. It explores the molecular and cellular components of these barriers and their roles in brain metastasis, highlighting the importance of this knowledge for identifying druggable targets to prevent or limit BM formation.

    Background

    Metastasis into the brain poses a chal

  • Any movement of the out

    • .